Difenamizole
Title: Difenamizole
CAS Registry Number: 20170-20-1
CAS Name: 2-(Dimethylamino)-N-(1,3-diphenyl-1H-pyrazol-5-yl)propanamide
Additional Names: 1,3-diphenyl-5-(2-dimethylaminopropionamido)pyrazole
Manufacturers' Codes: AP-14
Trademarks: Pasalin (Takeda)
Molecular Formula: C20H22N4O
Molecular Weight: 334.41
Percent Composition: C 71.83%, H 6.63%, N 16.75%, O 4.78%
Literature References: Prepn: Kameyama, Niwa, JP 68 6621 (1968 to Takeda), C.A. 69, 106704x (1968). Physicochemical properties and stability: Uda, Yashiki, Takeda Kenkyushoho 29, 42 (1970), C.A. 73, 28847n (1970). Pharmacology: Fukuda et al., ibid. 30, 389 (1971); Saji et al., ibid. 406; Nagawa et al., ibid. 427, C.A. 76, 108025v, 108021r, 108023t (1972), resp. Toxicity studies: Tanaka et al., Oyo Yakuri 6, 279 (1972). Mechanism of action studies: Yasuhara et al., ibid. 313. Acute toxicity: M. Hayashi et al., Gifu Daigaku Igakubu Kiyo 20, 360 (1972), C.A. 78, 92505e (1973). Review: Jpn. Med. Gaz. 10(11), 12 (1973).
Properties: White to pale yellow, odorless powder, mp 123-128°. Also reported as mp 120-122°. Freely sol in acetone, chloroform, benzene. Practically insol in water. Stable to heat, humidity and sunlight for 3 months. LD50 in mice (mg/kg): 103 i.v.; 186 i.p.; 525 s.c.; 560 orally (Hayashi).
Melting point: mp 123-128°; mp 120-122°
Toxicity data: LD50 in mice (mg/kg): 103 i.v.; 186 i.p.; 525 s.c.; 560 orally (Hayashi)
Therap-Cat: Analgesic, anti-inflammatory.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Pyrazoles.

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