4-Amino-3-phenylbutyric Acid
Title: 4-Amino-3-phenylbutyric Acid
CAS Registry Number: 1078-21-3
CAS Name: b-(Aminomethyl)benzenepropanoic acid
Additional Names: b-(aminomethyl)hydrocinnamic acid; 4-amino-3-phenylbutanoic acid; b-phenyl-g-aminobutyric acid; fenibut; phenibut; phenigamma; phenygam; PhGABA
Molecular Formula: C10H13NO2
Molecular Weight: 179.22
Percent Composition: C 67.02%, H 7.31%, N 7.82%, O 17.85%
Literature References: Prepn starting with a,g-diamino-b-phenylpropane: Jackson, Kenner, J. Chem. Soc. 1928, 1657. Alternate prepn: Cologne, Pouchol, Bull. Soc. Chim. Fr. 1962, 598. Pharmacology: R. A. Khaunina, Bull. Exp. Biol. Med. 57, 52 (1964). Structure-activity studies: idem, Farmakol. Toksikol. 31, 202 (1968). Activity studies of the isomers: eidem, Byull. Eksp. Biol. Med. 72, 49 (1971), C.A. 76, 81208t (1972). Review of pharmacology and clinical experience: I. Lapin, CNS Drug Rev. 7, 471-481 (2001).
Properties: mp 250-253° (dec).
Melting point: mp 250-253° (dec)
 
Derivative Type: Hydrobromide
CAS Registry Number: 103095-38-1
Molecular Formula: C10H13NO2.HBr
Molecular Weight: 260.13
Percent Composition: C 46.17%, H 5.42%, N 5.38%, O 12.30%, Br 30.72%
Properties: Irregular platelets from benzene, mp 114°.
Melting point: mp 114°
 
Derivative Type: Hydrochloride
CAS Registry Number: 3060-41-1
Molecular Formula: C10H13NO2.HCl
Molecular Weight: 215.68
Percent Composition: C 55.69%, H 6.54%, N 6.49%, O 14.84%, Cl 16.44%
Properties: LD50 in mice, rats (mg/kg): 900, 700 i.p. (Khaunina, 1964).
Toxicity data: LD50 in mice, rats (mg/kg): 900, 700 i.p. (Khaunina, 1964)
 
Therap-Cat: Anxiolytic.

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