4-Methyl-5-thiazoleethanol
Title: 4-Methyl-5-thiazoleethanol
CAS Registry Number: 137-00-8
CAS Name: 5-Hydroxyethyl-4-methylthiazole
Additional Names: 5-(2-hydroxyethyl)-4-methylthiazole; 4-methyl-5-(b-hydroxyethyl)thiazole
Molecular Formula: C6H9NOS
Molecular Weight: 143.21
Percent Composition: C 50.32%, H 6.33%, N 9.78%, O 11.17%, S 22.39%
Literature References: The thiazole moiety of thiamine (vitamin B1). Several syntheses, e.g., by condensing thioformamide with bromoacetopropanol: Buchman, J. Am. Chem. Soc. 58, 1803 (1936); or with g,g-dichloro-g,g-diacetodipropyl ether: Stein, Stevens, FR 945198 and GB 641426 (1947 and 1950 to Merck & Co.); Londergan, Schmitz, US 2654760 (1953 to du Pont).
Properties: Oily, viscous liquid. d424 1.196. Characteristic disagreeable odor of thiazole compds, becoming somewhat pleasant at extreme dilutions and imparting a nut-like flavor. bp7 135°; bp3 123-124°; bp1 103°. Sol in alcohol, ether, benzene, chloroform. Very sol in water.
Boiling point: bp7 135°; bp3 123-124°; bp1 103°
Density: d424 1.196
 
Derivative Type: Hydrochloride
Molecular Formula: C6H9NOS.HCl
Molecular Weight: 179.67
Percent Composition: C 40.11%, H 5.61%, N 7.80%, O 8.90%, S 17.85%, Cl 19.73%
Properties: Hygroscopic crystals, sol in water, alcohol.
 
Use: Intermediate in the synthesis of vitamin B1.

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