Bezitramide
Title: Bezitramide
CAS Registry Number: 15301-48-1
CAS Name: 1-[1-(3-Cyano-3,3-diphenylpropyl)-4-piperidinyl]-1,3-dihydro-3-(1-oxopropyl)-2H-benzimidazol-2-one
Additional Names: 1-[1-(3-cyano-3,3-diphenylpropyl)-4-piperidyl]-3-propionyl-2-benzimidazolinone; 1-(3-cyano-3,3-diphenylpropyl)-4-(2-oxo-3-propionyl-1-benzimidazolinyl)piperidine; benzitramide
Manufacturers' Codes: R-4845
Trademarks: Burgodin (Janssen)
Molecular Formula: C31H32N4O2
Molecular Weight: 492.61
Percent Composition: C 75.58%, H 6.55%, N 11.37%, O 6.50%
Literature References: Prepn: BE 633495; P. A. J. Janssen, US 3196157 (1963, 1965 both to Janssen). Pharmacology and clinical data: P. A. J. Janssen et al., Arzneim.-Forsch. 21, 862 (1971); W. K. P. Amery et al., ibid. 868; H. Knape, Anaesthesist 21, 251 (1972).
Properties: White crystalline powder, mp 145-149°. Also reported as pale yellow amorphous powder, mp 124.5-126°. Solubility of >1 g/100 ml in ethyl acetate, acetone, benzene, chloroform. Almost insol in water, dilute acids. LD50 orally in mice, rats: 2101, 141 mg/kg (Janssen).
Melting point: mp 145-149°; mp 124.5-126°
Toxicity data: LD50 orally in mice, rats: 2101, 141 mg/kg (Janssen)
NOTE: This is a controlled substance (opiate): 21 CFR, 1308.12.
Therap-Cat: Analgesic (narcotic).
Keywords: Analgesic (Narcotic).

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