Title: Cardiotoxin
CAS Registry Number: 11061-96-4
Literature References: One of the toxic principles from cobra venom. Isoln: Sarkar, J. Indian Chem. Soc. 21, 227 (1947). A single peptide chain composed of 60 amino acid residues cross-linked by four disulfide bridges with leucine and asparagine at the N and C terminals respectively: Narita, Lee, Biochem. Biophys. Res. Commun. 41, 339 (1970). Causes irreversible depolarization of cell membrane and contraction of skeletal and smooth muscle. Shows direct lytic and marked cardiotoxic activities, potentiated by phospholipase A and prevented by polyanions (heparin, RNA, gangliosides). Pharmacology: Lee et al., Arch. Exp. Pathol. Pharmakol. 259, 360 (1968).

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