Title: Iberiotoxin
CAS Registry Number: 129203-60-7
Additional Names: IbTX
Literature References: Peptide inhibitor of K+ channels isolated from the venom of the scorpion, Buthus tamulus. Single polypeptide chain of 37 amino acids with 3 disulfide bridges; mol wt 4.23 kDa. Isoln, purification and characterization: A. Galvez et al., J. Biol. Chem. 265, 11083 (1990). 3D structure determn by NMR: B. A. Johnson, E. E. Sugg, Biochemistry 31, 8151 (1992). Mode of action: S. Candia et al., Biophys. J. 63, 583 (1992). Synthesis of labeled mutant: A. Koschak et al., Biochemistry 36, 1943 (1997). Use as probe: W. A. A. Kunze et al., Pflügers Arch. 428, 300 (1994); G. Fauaz et al., Vascul. Pharmacol. 40, 127 (2003); Y. Tanaka et al., Arch. Pharmacol. 367, 35 (2003).
Use: Selective probe for high-conductance calcium-activated potassium channels.

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