Title: Ciclesonide
CAS Registry Number: 126544-47-6
CAS Name: (11b,16a)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione
Manufacturers' Codes: BY-9010
Trademarks: Alvesco (Altana)
Molecular Formula: C32H44O7
Molecular Weight: 540.69
Percent Composition: C 71.08%, H 8.20%, O 20.71%
Literature References: Inhaled corticosteroid. Prodrug converted to the active metabolite, ciclesonide-active principle, in the lung. Prepn: J. Calatayud et al., DE 4129535; eidem, US 5482934 (1992, 1996 both to Elmu). Pharmacokinetics and pharmacodynamics: S. Rohatagi et al., J. Clin. Pharmacol. 43, 365 (2003). Clinical evaluation in asthma: D. A. Taylor et al., Am. J. Respir. Crit. Care Med. 160, 237 (1999); in allergic rhinitis: B. M. W. Schmidt et al., J. Clin. Pharmacol. 39, 1062 (1999). Review of clinical experience: G. Dent, Curr. Opin. Invest. Drugs 3, 78-83 (2002).
Therap-Cat: Glucocorticoid.
Keywords: Glucocorticoid.

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