Disofenin
Title: Disofenin
CAS Registry Number: 65717-97-7
CAS Name: N-[2-[[2,6-Bis(1-methylethyl)phenyl]amino]2-oxoethyl]-N-(carboxymethyl)glycine
Additional Names: [[[(2,6-diisopropylphenyl)carbamoyl]methyl]imino]diacetic acid; (2,6-diisopropylacetanilido)iminodiacetic acid; N-(carboxymethyl)-N-[2-(2,6-diisopropylphenyl)amino]-2-oxoethylglycine; DISIDA
Molecular Formula: C18H26N2O5
Molecular Weight: 350.41
Percent Composition: C 61.70%, H 7.48%, N 7.99%, O 22.83%
Literature References: Iminodiacetic acid analog. Prepn of acid and 99mTc-complex: M. de Schrijver, DE 2723605; idem, US 4316883 (1977, 1982 both to Solco Basel). High yield synthesis of acid: M. P. Best et al., Aust. J. Chem. 35, 2371 (1982). Biodistribution: G. Subramanian et al., Nuklearmedizin Suppl. 16, 136 (1978). Chromatographic determn of radiochemical purity: A. M. Zimmer et al., Eur. J. Nucl. Med. 7, 88 (1982). Chemical and biological properties: B. Zmbova et al., Appl. Radiat. Isot. 38, 35 (1987). Pharmacokinetics: I. A. Fraser et al., Eur. J. Nucl. Med. 14, 431 (1988); J. E. Love et al., ibid. 436. Clinical evaluation as hepatobiliary imaging agent: R. C. Stadalnik et al., Radiology 140, 797 (1981).
Properties: White crystals, mp 196-198° (Zmbova). Also reported as crystals from water, mp 191-192.5° (Best); and as mp 166-175° (de Schrijver). Insol in water.
Melting point: mp 196-198° (Zmbova); mp 191-192.5° (Best); mp 166-175°
 
Derivative Type: 99mTc complex
Additional Names: 99mTc diisopropyl IDA; 99mTc-DISIDA
Trademarks: Hepatolite (DuPont)
Properties: Distribution coefficient (ethylene dichloride/water): 0.0086.
 
Therap-Cat: 99mTc-complex as diagnostic aid (radioactive imaging agent).

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