Title: Cotoin
CAS Registry Number: 479-21-0
CAS Name: (2,6-Dihydroxy-4-methoxyphenyl)phenylmethanone
Additional Names: 2,6-dihydroxy-4-methoxybenzophenone
Molecular Formula: C14H12O4
Molecular Weight: 244.24
Percent Composition: C 68.85%, H 4.95%, O 26.20%
Literature References: Crystalline principle from true coto bark, the bark of Aniba coto (Rusby) Kost, Lauraceae. Extraction procedure: Jobst, Hesse, Ann. 199, 17 (1879). Isoln from South American rosewood trees, Aniba rosaeodora Ducke and A. duckei Kost. Lauraceae: Gottlieb, Mors, J. Am. Chem. Soc. 80, 2263 (1958). Structure: Karrer, Lichtenstein, Helv. Chim. Acta 11, 789 (1928). Toxicity study: Jodbauer, Kurz, Biochem. Z. 74, 340 (1916).
Properties: Yellow needles from benzene, mp 131-132°. Sharp taste. Almost insol in water. Sol in alcohol, methanol, amyl alcohol, benzene, chloroform, ether, carbon bisulfide, acetone, solns of alkali hydroxides and carbonates. Solns are yellow. Slowly reduces Fehling's soln or ammoniacal AgNO3 in the cold. LD s.c. in frogs: 8 mg/kg (Jodbauer, Kurz).
Melting point: mp 131-132°
Toxicity data: LD s.c. in frogs: 8 mg/kg (Jodbauer, Kurz)
CAUTION: Irritates mucous membranes.
Status: This monograph has been retired and is no longer subject to revision or update.

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