Title: Dibucaine
CAS Registry Number: 85-79-0
CAS Name: 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide
Additional Names: 2-butoxy-N-(2-diethylaminoethyl)cinchoninamide; cinchocaine
Molecular Formula: C20H29N3O2
Molecular Weight: 343.46
Percent Composition: C 69.94%, H 8.51%, N 12.23%, O 9.32%
Literature References: Prepn: Miescher, US 1825623 (1931 to Ciba). Comprehensive description: G. R. Padmanabhan, Anal. Profiles Drug Subs. 12, 105-134 (1983). Spectrometric determn in pharmaceutical formulations: N. T. Abdel-Ghani et al., Farmaco 60, 419 (2005).
Properties: White to off-white powder; slight characteristic odor. mp 64°.
Melting point: mp 64°
Derivative Type: Hydrochloride
CAS Registry Number: 61-12-1
Trademarks: Nupercainal (Novartis)
Molecular Formula: C20H29N3O2.HCl
Molecular Weight: 379.92
Percent Composition: C 63.23%, H 7.96%, N 11.06%, O 8.42%, Cl 9.33%
Properties: Hygroscopic crystals. Dec 90-98°. uv max (1N HCl): 247, 320 nm (e 24700, 8810). Sol in 0.5 part water; freely sol in alcohol, acetone, chloroform; slightly sol in benzene, ethyl acetate and toluene (on warming); insol in ether and in oils. The aq soln, about 1 in 20, is faintly alkaline to litmus.
Absorption maximum: uv max (1N HCl): 247, 320 nm (e 24700, 8810)
Therap-Cat: Anesthetic (local).
Keywords: Anesthetic (Local).

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