Endralazine
Title: Endralazine
CAS Registry Number: 39715-02-1
CAS Name: 6-Benzoyl-5,6,7,8-tetrahydropyrido[4,3-c]pyridazin-3(2H)-one hydrazone
Additional Names: 6-benzoyl-3-hydrazino-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine
Molecular Formula: C14H15N5O
Molecular Weight: 269.30
Percent Composition: C 62.44%, H 5.61%, N 26.01%, O 5.94%
Literature References: Prepn: E. Schenker, DE 2221808; idem, US 3838125 (1972, 1974 both to Sandoz); E. Schenker, R. Salzmann, Arzneim.-Forsch. 29, 1835 (1979). Pharmacology: R. Salzmann et al., ibid. 1843. Hemodynamic study: H. U. Lehmann et al., Z. Cardiol. 66, 203 (1977). HPLC determn in human plasma: P. A. Reece et al., J. Chromatogr. 225, 151 (1981). Clinical pharmacology: F. C. Reubi, Eur. J. Clin. Pharmacol. 13, 185 (1978). Clinical study in hypertension: H. U. Lehmann et al., Med. Welt 29, 1007 (1978).
Properties: Crystals from acetonitrile/water, mp 220-223° (dec).
Melting point: mp 220-223° (dec)
 
Derivative Type: Methanesulfonate
CAS Registry Number: 65322-72-7
Additional Names: Endralazine mesylate
Manufacturers' Codes: BQ 22-708
Trademarks: Miretilan (Sandoz)
Molecular Formula: C14H15N5O.CH3SO3H
Molecular Weight: 365.41
Percent Composition: C 49.30%, H 5.24%, N 19.17%, O 17.51%, S 8.78%
Properties: Cryst, mp 185-188° (dec).
Melting point: mp 185-188° (dec)
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Hydrazines/Phthalazines.

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