Esaprazole
Title: Esaprazole
CAS Registry Number: 64204-55-3
CAS Name: N-Cyclohexyl-1-piperazineacetamide
Additional Names: 1-piperazinyl-4-methylenecarbonylcyclohexylamine; N-(1-piperazinylacetyl)cyclohexylamine; N-[(N-cyclohexylcarbamoyl)methyl]piperazine; hexaprazol(e); exaprazole
Manufacturers' Codes: C-63
Trademarks: Prazol (Corvi)
Molecular Formula: C12H23N3O
Molecular Weight: 225.33
Percent Composition: C 63.96%, H 10.29%, N 18.65%, O 7.10%
Literature References: Prepn: C. Corvi-Mora, DE 2702537; idem, US 4123530 (1977, 1978 both to Camillo Corvi). Metabolism in animals and man: P. Ventura et al., Farmaco Ed. Prat. 39, 190 (1984). Cytoprotective activity: B. Lumachi, R. Scuri, Drugs Exp. Clin. Res. 11, 693 (1985); and pharmacology: R. Scuri et al., Boll. Chim. Farm. 123, 425 (1983). Pharmacology: G. Coruzzi et al., Farmaco Ed. Prat. 40, 313 (1985); G. Coruzzi et al., ibid. 324. Antisecretory activity in humans: L. Erembourg et al., Int. J. Clin. Pharmacol. Res. 7, 95 (1987). HPLC determn in biological fluids: M. A. Girometta et al., J. Chromatogr. 383, 85 (1986). Clinical trial in comparison with cimetidine: L. Capurso et al., Clin. Trials J. 23, 293 (1986).
Properties: Residue, mp 111-112°. bp0.5 190°. LD50 in mice (mg/kg): 1974 orally; 271 i.v.; in rats (mg/kg): 3900 orally (Corvi-Mora).
Melting point: mp 111-112°
Boiling point: bp0.5 190°
Toxicity data: LD50 in mice (mg/kg): 1974 orally; 271 i.v.; in rats (mg/kg): 3900 orally (Corvi-Mora)
 
Derivative Type: Hydrochloride
Manufacturers' Codes: CO-1063
Molecular Formula: C12H23N3O.HCl
Molecular Weight: 261.79
Percent Composition: C 55.05%, H 9.24%, N 16.05%, O 6.11%, Cl 13.54%
 
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative.

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