Title: Etoxazole
CAS Registry Number: 153233-91-1
CAS Name: 2-(2,6-Difluorophenyl)-4-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydrooxazole
Additional Names: 4-(4-tert-butyl-2-ethoxyphenyl)-2-(2,6-difluorophenyl)-4,5-dihydrooxazole; 2-(2,6-difluorophenyl)-4-(2-ethoxy-4-tert-butylphenyl)-2-oxazoline
Manufacturers' Codes: YI-5301
Trademarks: Baroque (Yashima); TetraSan (Valent); Zeal (Valent)
Molecular Formula: C21H23F2NO2
Molecular Weight: 359.41
Percent Composition: C 70.18%, H 6.45%, F 10.57%, N 3.90%, O 8.90%
Literature References: Insect growth regulator; molting inhibitor for control of mites and aphids on fruits, vegetables and ornamentals. Prepn: J. Suzuki et al., WO 9322297; eidem, US 5478855 (1993, 1995 both to Yashima); and ovicidal and insecticidal activity: idem et al., J. Pestic. Sci. 26, 215 (2001). Comprehensive description: T. Ishida et al., Brighton Crop Prot. Conf. - Pests Dis. 1994, 37-44. Efficacy as a tick control agent: Y. Tamura et al., Med. Entomol. Zool. 55, 303 (2004).
Properties: Colorless crystals from hexane, mp 101-102°. Vapor pressure (25°): 2.18´10-6 Pa. Log P (octanol/water): 5.59 at 25°. Soly at 20°(g/l solvent): water 75.4´10-6; methanol 100; acetone 450; THF 850; n-hexane 15. LD50 in rats (mg/kg): >5000 orally; >2000 dermally. LC50 (96 hr) in Japanese carp: 0.89 mg/l (Ishida).
Melting point: mp 101-102°
Log P: Log P (octanol/water): 5.59 at 25°
Toxicity data: LD50 in rats (mg/kg): >5000 orally; >2000 dermally; LC50 (96 hr) in Japanese carp: 0.89 mg/l (Ishida)
Use: Acaricide.

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