Title: Fenarimol
CAS Registry Number: 60168-88-9
CAS Name: a-(2-Chlorophenyl)-a-(4-chlorophenyl)-5-pyrimidinemethanol
Additional Names: 2,4¢-dichloro-a-(pyrimidin-5-yl)benzhydryl alcohol
Manufacturers' Codes: EL-222
Trademarks: Rubigan (Gowan)
Molecular Formula: C17H12Cl2N2O
Molecular Weight: 331.20
Percent Composition: C 61.65%, H 3.65%, Cl 21.41%, N 8.46%, O 4.83%
Literature References: Prophylactic and curative leaf fungicide; inhibits ergosterol biosynthesis. Prepn: NL 6806106; H. M. Taylor et al., US 3818009 (1968, 1974 both to Lilly). Improved prepn: eidem, US 3869456; use as fungicide: eidem, US 3887708 (both 1975 to Lilly). Mode of action, efficacy against various fungi: H. Buchenauer, Proc. Br. Crop Prot. Conf. - Pests Dis. 1977, 699. Absorption by leaf tissue, local systemic activity: I. F. Brown, H. R. Hall, ibid. 1981(2), 573. In control of apple scab: J. M. Olivier, J. Guillaumes, Monogr. Br. Crop Prot. Counc. 31, 485 (1985). Post-infection efficacy: A. L. O'Leary, T. B. Sutton, Phytopathology 76, 119 (1986). Brief review: J.-M. Beraud et al., Def. Veg. 34, 17 (1980).
Properties: White odorless crystals, mp 117-119°. Practically insol in water (13.7 ppm at pH 7). Sol in most organic solvents. Vapor pressure at 25° <10-7 millibar. LD50 in mice, rats (mg/kg): 4500, 2500 orally (Beraud).
Melting point: mp 117-119°
Toxicity data: LD50 in mice, rats (mg/kg): 4500, 2500 orally (Beraud)
Use: Plant fungicide.

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