Title: Landiolol
CAS Registry Number: 133242-30-5
CAS Name: 4-[(2S)-2-Hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]benzenepropanoic acid [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester
Additional Names: (-)-2,2-dimethyl-1,3-dioxolan-4S-ylmethyl 3-[4-[3-[2-(morpholinocarbonylamino)ethylamino]-2S-hydroxypropoxy]phenyl]propionate
Molecular Formula: C25H39N3O8
Molecular Weight: 509.59
Percent Composition: C 58.92%, H 7.71%, N 8.25%, O 25.12%
Literature References: Cardioselective b-adrenergic blocker. Prepn: S. Iguchi et al., EP 397031; US 5013734 (1990, 1991 both to Ono Pharm.); idem et al., Chem. Pharm. Bull. 40, 462 (1992). Electrophysiology: A. Sugiyama et al., J. Cardiovasc. Pharmacol. 34, 70 (1999). Clinical pharmacology: A. Kitamura et al., Eur. J. Clin. Pharmacol. 51, 467 (1997). Clinical pharmacokinetics in patients with cardiac tachyarrhythmias: H. Atarashi et al., Clin. Pharmacol. Ther. 68, 143 (2000).
Derivative Type: Hydrochloride
CAS Registry Number: 144481-98-1
Manufacturers' Codes: ONO-1101
Trademarks: Onoact (Ono)
Molecular Formula: C25H39N3O8.HCl
Molecular Weight: 546.05
Percent Composition: C 54.99%, H 7.38%, N 7.70%, O 23.44%, Cl 6.49%
Properties: mp 125.4°. LD50 in mice (mg/kg): 290 i.v. (Iguchi).
Melting point: mp 125.4°
Toxicity data: LD50 in mice (mg/kg): 290 i.v. (Iguchi)
Therap-Cat: Antiarrhythmic.
Keywords: Antiarrhythmic; ?Adrenergic Blocker.

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