Title: Metoserpate
CAS Registry Number: 1178-28-5
CAS Name: (3b,16b,17a,18a,20a)-11,17,18-Trimethoxyyohimban-16-carboxylic acid methyl ester
Additional Names: O-methyl-18-epireserpic acid methyl ester; 18-epi-O-methylreserpic acid methyl ester; methyl 18-epi-O-methylreserpate; methyl O-methyl-18-epireserpate
Molecular Formula: C24H32N2O5
Molecular Weight: 428.52
Percent Composition: C 67.27%, H 7.53%, N 6.54%, O 18.67%
Literature References: Prepn: M. M. Robison et al., Experientia 17, 14 (1961); eidem, J. Am. Chem. Soc. 83, 2694 (1961); R. A. Lucas et al., US 3120532; US 3126390; M. M. Robison, R. A. Lucas, US 3151117 (all 1964 to Ciba); Ziegler, US 3264303 (1966 to Ciba).
Properties: Crystals from benzene + cyclohexane, dec 248.5-251.5°, also reported as 239-241°. [a]D26 -37.5° (CHCl3).
Optical Rotation: [a]D26 -37.5° (CHCl3)
Derivative Type: Hydrochloride
CAS Registry Number: 1178-29-6
Manufacturers' Codes: Su-9064
Trademarks: Avicalm (Squibb); Pacitran (obsolete) (Squibb)
Molecular Formula: C24H32N2O5.HCl
Molecular Weight: 464.98
Percent Composition: C 61.99%, H 7.15%, N 6.02%, O 17.20%, Cl 7.62%
Properties: Solid, dec 240-242°. Sol in water.
Therap-Cat-Vet: Sedative.
Status: This monograph has been retired and is no longer subject to revision or update.

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