Title: Proxyphylline
CAS Registry Number: 603-00-9
CAS Name: 3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6-dione
Additional Names: 7-(2-hydroxypropyl)theophylline
Trademarks: Brontyl (Reckitt Benckiser); Spasmolysin (Kade); Theon (Bock)
Molecular Formula: C10H14N4O3
Molecular Weight: 238.24
Percent Composition: C 50.41%, H 5.92%, N 23.52%, O 20.15%
Literature References: Smooth muscle relaxant. Prepd by refluxing 1-chloro-2-propanol with theophylline in an alkaline medium: Rice, US 2715125 (1955 to Gane's Chem. Works).
Properties: Crystals from abs ethanol, mp 135-136°. One gram dissolves in about 1 ml water, in 14 ml abs ethanol. More sol in boiling ethanol. pH of a 5% aq soln 5.5 to 7.0. Solns may be sterilized by heating.
Melting point: mp 135-136°
Therap-Cat: Bronchodilator; vasodilator.
Keywords: Bronchodilator; Xanthine Derivatives.

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