Talaporfin
Title: Talaporfin
CAS Registry Number: 110230-98-3
CAS Name: N-[[(7S,8S)-3-Carboxy-7-(2-carboxyethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-21H,23H-porphin-5-yl]acetyl]-L-aspartic acid
Additional Names: (2S,3S)-18-carboxy-20-[N-(S)-1,2-dicarboxyethyl]carbamoylmethyl-13-ethyl-3,7,12,17-tetramethyl-8-vinylchlorin-2-propanoic acid; mono-L-aspartyl chlorin e6; NPe6
Molecular Formula: C38H41N5O9
Molecular Weight: 711.76
Percent Composition: C 64.12%, H 5.81%, N 9.84%, O 20.23%
Literature References: Semisynthetic derivative of chlorin e6, q.v. Photosensitizer activated at 664 nm by laser or light-emitting diode-based light infusion device. Causes irreversible tumor blood vessel closure. Prepn: J. C. Bommer, B. F. Burnham, EP 168831; eidem, US 4675338 (1986, 1987 both to Nippon Petrochemicals). Photophysical properties: J. D. Spikes, J. C. Bommer, J. Photochem. Photobiol. B 17, 135 (1993); L. Li et al., ibid. 67, 51 (2002). Chemical and NMR structural studies: S. Gomi et al., Heterocycles 48, 2231 (1998). Safety assessment in treatment of refractory solid tumors: R. A. Lustig et al., Cancer 98, 1767 (2003). Clinical evaluation in lung cancer: H. Kato et al., Lung Cancer 42, 103 (2003).
Properties: Dark blue-green powder. Sol in water. Absorption max (phosphate buffer, pH 7.4): 400, 654 nm (e 180000, 40000). Absorption max (p-dioxane): 401.7, 663.5 nm (EmM 111, 38). Hygroscopic and light sensitive. Store under vacuum; protect from light.
Absorption maximum: Absorption max (phosphate buffer, pH 7.4): 400, 654 nm (e 180000, 40000); Absorption max (p-dioxane): 401.7, 663.5 nm (EmM 111, 38)
 
Derivative Type: Tetrasodium salt
CAS Registry Number: 220201-34-3
Additional Names: Talaporfin sodium
Manufacturers' Codes: LS-11; ME-2906
Trademarks: Laserphyrin (Meiji)
Molecular Formula: C38H37N5Na4O9
Molecular Weight: 799.69
Percent Composition: C 57.07%, H 4.66%, N 8.76%, Na 11.50%, O 18.01%
 
Therap-Cat: Antineoplastic (photosensitizer).
Keywords: Antineoplastic (Photosensitizer).

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