Tioxolone
Title: Tioxolone
CAS Registry Number: 4991-65-5
CAS Name: 6-Hydroxy-1,3-benzoxathiol-2-one
Additional Names: 6-hydroxy-2-oxo-1,3-benzoxathiole; thioxolone
Trademarks: Camyna (Nycomed); Stepin (Basotherm)
Molecular Formula: C7H4O3S
Molecular Weight: 168.17
Percent Composition: C 49.99%, H 2.40%, O 28.54%, S 19.07%
Literature References: Prepd from resorcinol and ammonium thiocyanate in presence of copper sulfate: Werner, US 2332418 (1943 to Winthrop); Urushibara, Koga, Bull. Chem. Soc. Jpn. 29, 419 (1956); Berg, Fiedler, US 2886488 (1959 to Thomae). Formerly believed to be the 4-hydroxy isomer: Fiedler, Ber. 95, 1771 (1962).
Properties: Crystals from water, mp 160°. Practically insol in water. Sol in ethanol, isopropanol, propylene glycol, ether, benzene, toluene. Hydrolyzed by alkali.
Melting point: mp 160°
 
Derivative Type: Combination with hydrocortisone
CAS Registry Number: 8064-73-1
Trademarks: Psoil (Basotherm)
 
Therap-Cat: Antiseborrheic; antiacne.
Keywords: Antiacne; Antiseborrheic.

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