Triamcinolone Benetonide
Title: Triamcinolone Benetonide
CAS Registry Number: 31002-79-6
CAS Name: (11b,16a)-21-[3-(Benzoylamino)-2-methyl-1-oxopropoxy]-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
Additional Names: 9-fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-ester with N-benzoyl-2-methyl-b-alanine; 9a-fluoro-16a-hydroxyprednisolone 16a,17a-acetonide 21-(b-benzoylamino)isobutyrate; triamcinolone acetonide b-benzoylaminoisobutyrate; TBI
Trademarks: Tibicorten (Stiefel)
Molecular Formula: C35H42FNO8
Molecular Weight: 623.71
Percent Composition: C 67.40%, H 6.79%, F 3.05%, N 2.25%, O 20.52%
Literature References: Prepn: C. Cavazza et al., DE 2047218; eidem, US 3749712 (1971, 1973 both to Sigma-Tau). Pharmacology: E. T. Ordonez, Arzneim.-Forsch. 21, 248 (1971). Percutaneous absorption by rats and rabbits: W. H. Down et al., Toxicol. Lett. 1, 95 (1977). Clinical study: D. J. Tazelaar, J. Int. Med. Res. 5, 338 (1977). HPLC analysis: S. Muck et al., Boll. Chim. Farm. 120, 240 (1981). For structure see Triamcinolone Acetonide.
Properties: Crystalline powder, mp 203-207°. [a]D20 +96 ±3° (c = 1 in ethanol). Sol in methanol, acetone, ethanol, dioxane, pyridine, DMF, chloroform. Insol in water.
Melting point: mp 203-207°
Optical Rotation: [a]D20 +96 ±3° (c = 1 in ethanol)
Therap-Cat: Glucocorticoid; anti-inflammatory (topical).
Keywords: Glucocorticoid.

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