Triethylenethiophosphoramide
Title: Triethylenethiophosphoramide
CAS Registry Number: 52-24-4
CAS Name: 1,1¢,1¢¢-Phosphinothioylidynetrisaziridine
Additional Names: tris(1-aziridinyl)phosphine sulfide; thiotepa
Trademarks: Tespamin (Sumitomo); Tifosyl (Astra)
Molecular Formula: C6H12N3PS
Molecular Weight: 189.22
Percent Composition: C 38.08%, H 6.39%, N 22.21%, P 16.37%, S 16.95%
Literature References: Preparation: Kuh, Seeger, US 2670347 (1954 to Am. Cyanamid); Saijo, Endo, JP 55 218 (1955 to Semimoto Chem.). Toxicity data: Scherf et al., Arzneim.-Forsch. 20, 1467 (1970). Review of carcinogenicity studies: IARC Monographs 9, 85-94 (1975).
Properties: Crystals from pentane or ether, mp 51.5°. Soly in water at 25°: 19 g/100 ml. Freely sol in alc; sol in benzene, ether, chloroform. LD50 i.v. in rats: 15 mg/kg (Scherf).
Melting point: mp 51.5°
Toxicity data: LD50 i.v. in rats: 15 mg/kg (Scherf)
CAUTION: This substance is listed as a known human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-249.
Use: Insect sterilant.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Ethylenimines and Methylmelamines.

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