Title: Adipsin
CAS Registry Number: 104118-48-1
Literature References: Serine protease homolog synthesized by mammalian adipocytes and secreted into the bloodstream; also produced by sciatic nerve. Developmentally regulated glycoprotein; mol wt ranges from 37-44 kilodaltons depending on the degree of glycosylation. Circulating levels of adipsin protein are reduced in certain genetic and experimental models of obesity. Originally identified as a 28 kDa protein encoded by a cDNA clone corresponding to messenger RNA specifically induced during adipocyte differentiation: B. M. Spiegelman et al., J. Biol. Chem. 258, 10083 (1983). Nucleotide analysis and predicted amino acid sequence: K. S. Cook et al., Proc. Natl. Acad. Sci. USA 82, 6480 (1985). Structure of adipsin gene: H. Y. Min, B. M. Spiegelman, Nucleic Acids Res. 14, 8879 (1986). Isoln from adipose tissue, reportedly the primary site of synthesis, and from sciatic nerve: K. S. Cook et al., Science 237, 402 (1987). Studies in murine obesity models and potential biological role: J. S. Flier et al., ibid. 405.

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