Alclofenac
Title: Alclofenac
CAS Registry Number: 22131-79-9
CAS Name: 3-Chloro-4-(2-propenyloxy)benzeneacetic acid
Additional Names: [4-(allyloxy)-3-chlorophenyl]acetic acid
Manufacturers' Codes: W-7320
Trademarks: Allopydin (Chugai); Epinal (Kyorin); Mervan (Continental Pharma); Reufenac (Zambon)
Molecular Formula: C11H11ClO3
Molecular Weight: 226.66
Percent Composition: C 58.29%, H 4.89%, Cl 15.64%, O 21.18%
Literature References: Prepn: N. P. Buu-Hoi et al., BE 704368 (1968 to Madan). Pharmacology: eidem, Naturwissenschaften 56, 330 (1969). Series of articles on pharmacology, toxicology and metabolism: Arzneim.-Forsch. 20, 610-636 (1970). Toxicity data: G. Lambelin et al., ibid. 618. Clinical studies: F. Lambotte, ibid. 569; Van Hoek, Curr. Ther. Res. 12, 551 (1970).
Properties: Prisms from cyclohexane, mp 92-93°. LD50 in mice, rats (mg/kg): 1100, 1050 orally; 600, 630 s.c.; 555, 530 i.p. (Lambelin).
Melting point: mp 92-93°
Toxicity data: LD50 in mice, rats (mg/kg): 1100, 1050 orally; 600, 630 s.c.; 555, 530 i.p. (Lambelin)
 
Derivative Type: Monoethanolamine complex
CAS Registry Number: 22131-80-2
Trademarks: Mirvan (Continental Pharma)
Molecular Formula: C13H18ClNO4
Molecular Weight: 287.74
Percent Composition: C 54.26%, H 6.31%, Cl 12.32%, N 4.87%, O 22.24%
 
Therap-Cat: Analgesic; antipyretic; anti-inflammatory.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives; Antipyretic.

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