Angeli's Salt
Title: Angeli's Salt
CAS Registry Number: 13826-64-7
CAS Name: Hyponitric acid disodium salt
Additional Names: sodium N-nitrohydroxylaminate; sodium a-oxyhyponitrite; sodium trioxodinitrate
Molecular Formula: N2Na2O3
Molecular Weight: 121.99
Percent Composition: N 22.96%, Na 37.69%, O 39.35%
Line Formula: Na2(ONNO2)
Literature References: Highly oxidizing compound; decomposes to produce nitroxyl (HNO). Prepn: A. Angeli, Gazz. Chim. Ital. 26, 17 (1896); and uv spectrum: C. C. Addison et al., J. Chem. Soc. 1952, 338. Crystal structure of monohydrate: H. Hope, M. R. Sequeira, Inorg. Chem. 12, 286 (1973). Reactivity studies: P. A. S. Smith, G. E. Hein, J. Am. Chem. Soc. 82, 5731 (1960); L. Torun et al., Tetrahedron Lett. 40, 5279 (1999). Decomposition studies: F. T. Bonner, B. Ravid, Inorg. Chem. 14, 558 (1975); C. M. Maragos et al., J. Med. Chem. 34, 3242 (1991). pH-dependent cytotoxicity: D. A. Stoyanovsky et al., ibid. 47, 210 (2004).
Properties: White, microcrystalline powder. Very sol in water. d 2.26 (monohydrate). uv max (0.1 M NaOH): 248 nm (e 8300). uv max (pH 7.4 phosphate buffer): 237 nm (e 6100).
Absorption maximum: uv max (0.1 M NaOH): 248 nm (e 8300); uv max (pH 7.4 phosphate buffer): 237 nm (e 6100)
Density: d 2.26 (monohydrate)
Use: HNO/NO- donor in biochemical model studies.

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