Angiostatin

Literature References: Naturally occurring inhibitor of angiogenesis that suppresses the growth of primary and metastatic tumors. 38 kDa protein generated by the cancer-mediated proteolysis of plasminogen, q.v.; amino acid sequence corresponds to the first four kringle domains. Isoln, amino acid sequence and bioactivity: M. S. O'Reilly et al., Cell 79, 315 (1994). Review of discovery: R. Vile, Curr. Biol. 5, 10-13 (1995). Effect on human carcinomas in mice: M. S. O'Reilly et al., Nat. Med. 2, 689 (1996). Mechanism of angiostatin generation: S. Gately et al., Proc. Natl. Acad. Sci. USA 94, 10868 (1997).