Antazoline
Title: Antazoline
CAS Registry Number: 91-75-8
CAS Name: 4,5-Dihydro-N-phenyl-N-(phenylmethyl)-1H-imidazole-2-methanamine
Additional Names: 2-(N-benzylanilinomethyl)-2-imidazoline; phenazoline; 2-(N-phenyl-N-benzylaminomethyl)imidazoline; imidamine
Manufacturers' Codes: 5512-M
Molecular Formula: C17H19N3
Molecular Weight: 265.35
Percent Composition: C 76.95%, H 7.22%, N 15.84%
Literature References: Prepn: Miescher, Klarer, US 2449241 (1948 to Ciba). HPLC determn in ophthalmic solutions: S. C. Ruckmick et al., J. Pharm. Sci. 84, 502 (1995). Clinical trial in combination with naphazoline in allergic conjunctivitis: M. B. Abelson et al., Arch. Ophthalmol. 108, 520 (1990).
Properties: Crystals, mp 120-122°.
Melting point: mp 120-122°
 
Derivative Type: Hydrochloride
CAS Registry Number: 2508-72-7
Trademarks: Antistine (Novartis); Antasten (Novartis)
Molecular Formula: C17H19N3.HCl
Molecular Weight: 301.81
Percent Composition: C 67.65%, H 6.68%, N 13.92%, Cl 11.75%
Properties: Bitter crystals producing temporary numbness of the tongue. mp 237-241°. uv max: 242 nm (E1%1cm 495 to 515); min 222 nm. One gram dissolves in 40 ml water, in 25 ml alc. Practically insol in ether, benzene, chloroform. pH (1% aq soln): 6.3.
Melting point: mp 237-241°
Absorption maximum: uv max: 242 nm (E1%1cm 495 to 515)
 
Derivative Type: Phosphate
CAS Registry Number: 154-68-7
Molecular Formula: C17H19N3.H3PO4
Molecular Weight: 363.35
Percent Composition: C 56.19%, H 6.10%, N 11.56%, P 8.52%, O 17.61%
Properties: Crystals. Bitter taste. mp 194-198°. Sol in water. Sparingly sol in methanol. Practically insol in benzene, ether. pH (2% aq soln): 4.5.
Melting point: mp 194-198°
 
Therap-Cat: Antihistaminic.
Therap-Cat-Vet: Antihistaminic.
Keywords: Antihistaminic.

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