Atosiban
Title: Atosiban
CAS Registry Number: 90779-69-4
CAS Name: 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin
Additional Names: 1-(3-mercaptopropionic acid)-2-[3-(p-ethoxyphenyl)-D-alanine]-4-L-threonine-8-L-ornithineoxytocin; 1-deamino-2-D-tyr-(OEt)-4-thr-8-orn-oxytocin; antocin; dTVT
Manufacturers' Codes: ORF-22164; F-314; RWJ-22164; CAP-440
Trademarks: Tractocile (Ferring)
Molecular Formula: C43H67N11O12S2
Molecular Weight: 994.19
Percent Composition: C 51.95%, H 6.79%, N 15.50%, O 19.31%, S 6.45%
Literature References: Oxytocin antagonist. Prepn: P. O. R. Melin, J. A. Trojnar, EP 112809; eidem, US 4504469 (1984, 1985 both to Ferring). Mechanism of action: A. Lopez Bernal et al., Br. J. Obstet. Gynaecol. 96, 1108 (1989). Effect on in vitro contractility of myometrium: V. A. Kinsler et al., ibid. 103, 373 (1996). Clinical pharmacokinetics: T. M. Goodwin et al., Am. J. Obstet. Gynecol. 173, 913 (1995). Clinical trial: T. M. Goodwin et al., ibid. 170, 474 (1994).
Therap-Cat: Tocolytic.
Keywords: Tocolytic.

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