Benorylate
Title: Benorylate
CAS Registry Number: 5003-48-5
CAS Name: 2-(Acetyloxy)benzoic acid 4-(acetylamino)phenyl ester
Additional Names: salicylic acid acetate, ester with 4-hydroxyacetanilide; 2-acetoxy-4¢-(acetamino)phenylbenzoate; p-acetamidophenyl acetylsalicylate; 4¢-(acetamido)phenyl-2-acetoxybenzoate; fenasprate
Manufacturers' Codes: Win-11450
Trademarks: Benoral (Sanofi Winthrop); Benortan (Sanofi Winthrop); Salipran (Evans)
Molecular Formula: C17H15NO5
Molecular Weight: 313.30
Percent Composition: C 65.17%, H 4.83%, N 4.47%, O 25.53%
Literature References: Prepn: NL 6504517 (1965 to Sterwin), C.A. 64, 8097c (1966), corresp to GB 1101747 (1968); Robertson, US 3431293 and Miller, GB 1168289 (both 1969 to Sterling Drug). Pharmacological investigations: Rosner et al., Therapie 23, 525 (1968); Raab, Arzneim.-Forsch. 21, 1662 (1971). Pharmacokinetic studies in animals: Liss, Palme, ibid. 19, 1177 (1969). Clinical evaluation: Bain, Burt, Clin. Trials J. 7, 307 (1970); Cardoe, ibid. 313.
Properties: Crystals from methanol or ethanol, mp 175-176°. LD50 in mice, rats (mg/ml): 2000, ~10000 orally; 1255, 1830 i.p. (Robertson).
Melting point: mp 175-176°
Toxicity data: LD50 in mice, rats (mg/ml): 2000, ~10000 orally; 1255, 1830 i.p. (Robertson)
Therap-Cat: Analgesic; anti-inflammatory; antipyretic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives; Antipyretic.

Others monographs:
Fluoboric AcidButyrolactoneHydracrylic AcidMaleanilic Acid
RavuconazoleBiotinHNEPentabromoacetone
TetrachlorvinphosWilkinson's CatalystSchradanHalethazole
IndanofanPumactantPyriminilThromboxanes
©2016 DrugLead US FDA&EMEA