Bietaserpine
Title: Bietaserpine
CAS Registry Number: 53-18-9
CAS Name: (3b,16b,17a,18b,20a)-1-[2-(Diethylamino)ethyl]-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
Additional Names: 1-[2-(diethylamino)ethyl]-18b-hydroxy-11,17a-dimethoxy-3b,20a-yohimban-16b-carboxylic acid methyl ester, 3,4,5-trimethoxybenzoate ester; 1-[2-(diethylamino)ethyl]reserpine
Molecular Formula: C39H53N3O9
Molecular Weight: 707.85
Percent Composition: C 66.17%, H 7.55%, N 5.94%, O 20.34%
Literature References: Prepn: Buzas, Régnier, C.R. Hebd. Seances Acad. Sci. 250, 1340 (1960); Buzas et al., FR 1256524 (1961 to Dautreville & Lebas and Andre Buzas), C.A. 57, 2273e (1962); Buzas et al., FR M102 C.A. 58, 9159a (1963); GB 894866 (1961, 1962 both to Soc. Nogentaise de Prods. Chim. and Andre Buzas). Pharmacology: Garattini et al., J. Pharm. Pharmacol. 13, 548 (1961); Quevauviller et al., Therapie 18, 1429 (1963); Guerrin et al., C.R. Seances Soc. Biol. Ses Fil. 158, 1096 (1964); P. Berthaux, M. Neuman, Arzneim.-Forsch. 14, 1040 (1964).
Properties: Free base, [a]D17 -121° (c = 2 in CHCl3). Sol in dil acids and the usual organic solvents except cyclohexane and petr ether.
Optical Rotation: [a]D17 -121° (c = 2 in CHCl3)
 
Derivative Type: Bitartrate
CAS Registry Number: 1111-44-0
Manufacturers' Codes: DL-152
Trademarks: Tensibar (Clin-Comar-Byla)
Molecular Formula: C39H53N3O9.C4H6O6
Molecular Weight: 857.94
Percent Composition: C 60.20%, H 6.93%, N 4.90%, O 27.97%
Properties: Dec 145-150°. LD50 in mice (mg/kg): 620 orally; 430 i.p.; 215 i.v. (Berthaux, Neuman).
Toxicity data: LD50 in mice (mg/kg): 620 orally; 430 i.p.; 215 i.v. (Berthaux, Neuman)
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Reserpine Derivatives.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

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