Bitolterol
Title: Bitolterol
CAS Registry Number: 30392-40-6
CAS Name: 4-Methylbenzoic acid 4-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,2-phenylene ester
Additional Names: p-toluic acid 4-[2-(t-butylamino)-1-hydroxethyl]-o-phenylene ester; a-[(tert-butylamino)methyl]-3,4-dihydroxybenzyl alcohol 3,4-di-p-toluate
Molecular Formula: C28H31NO5
Molecular Weight: 461.55
Percent Composition: C 72.86%, H 6.77%, N 3.03%, O 17.33%
Literature References: b2-Adrenergic agonist; a diester of N-tert-butylnorepinephrine. Prepn: H. Minatoya et al., DE 2015573; eidem, US 4138581 (1970, 1979 both to Sterling); B. F. Tullar et al., J. Med. Chem. 19, 834 (1976). Pharmacology: H. Minatoya, J. Pharmacol. Exp. Ther. 206, 515 (1978). Metabolism and excretion: T. Aimoto et al., Xenobiotica 9, 173 (1979). Comparative clinical studies with isoproterenol, q.v., in asthma: J. L. Pinnas et al., J. Allergy Clin. Immunol. 79, 768 (1987); R. A. Nathan et al., ibid. 822. Review: S. B. Walker et al., Pharmacotherapy 5, 127-137 (1985).
 
Derivative Type: Methanesulfonate
CAS Registry Number: 30392-41-7
Additional Names: Bitolterol mesylate
Manufacturers' Codes: Win-32784
Trademarks: Biterol (Winthrop); Effectin (Winthrop); Tornalate (Sterling Winthrop)
Molecular Formula: C28H31NO5.CH3SO3H
Molecular Weight: 557.66
Percent Composition: C 62.46%, H 6.33%, N 2.51%, O 22.95%, S 5.75%
Properties: White crystalline powder, mp 170-172°. Sol in DMSO.
Melting point: mp 170-172°
 
Therap-Cat: Bronchodilator.
Keywords: ?Adrenergic Agonist; Bronchodilator; Ephedrine Derivatives.

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