Bone Morphogenetic Proteins
Title: Bone Morphogenetic Proteins
Additional Names: Bone morphogenic factors; bone morphogenic proteins; BMPs
Literature References: Multifunctional cytokines that induce formation of cartilage and bone; originally isolated from demineralized bone matrix. Structurally related to the transforming growth factor-b (TGF-b) superfamily; at least 15 closely related forms exist. All are dimers linked by 7 disulfide bonds. Prepn from rabbit bone: M. R. Urist et al., Proc. Natl. Acad. Sci. USA 76, 1828 (1979); from human bone: idem et al., Proc. Soc. Exp. Biol. Med. 173, 194 (1983). Clinical evaluations in bone repair: E. E. Johnson et al., Clin. Orthop. Relat. Res. 230, 249, 257 (1988). Review of purification and structures of BMP-1 through BMP-7: J. M. Wozney, Prog. Growth Factor Res. 1, 267-280 (1989); and osteogenic activity: idem, Mol. Reprod. Dev. 32, 160-167 (1992). Review of potential clinical applications and delivery strategies: C. A. Kirker-Head, Adv. Drug Delivery Rev. 43, 65-92 (2000); of clinical studies in human bone regeneration: E. H. J. Groeneveld, E. H. Burger, Eur. J. Endocrinol. 142, 9-21 (2000); of clinical efficacy and safety: P. J. Harwood, P. V. Giannoudis, Expert Opin. Drug Safety 4, 75-89 (2005).
Derivative Type: BMP-2
Additional Names: BMP-2A
Literature References: Mature human form is a homodimer, mol wt 32 kDa. Each monomer consists of 114 amino acid residues. Review of bioactivity: E. H Riley et al., Clin. Orthop. Relat. Res. 324, 39-46 (1996).
Derivative Type: BMP-7
Additional Names: Osteogenic protein-1; OP-1
Literature References: Mature human form is a homodimer, mol wt 32-36 kDa. Each monomer consists of 139 amino acid residues. Prepn of recombinant human BMP-7 (rhBMP-7): T. K. Sampath et al., J. Biol. Chem. 267, 20352 (1992). Review of bioactivity and potential clinical applications: S. D. Cook, D. C. Rueger, Clin. Orthop. Relat. Res. 324, 29-38 (1996).
Derivative Type: Dibotermin alfa
CAS Registry Number: 246539-15-1
CAS Name: Bone morphogenetic protein 2 (human recombinant rhBMP-2)
Literature References: Glycosylated, disulfide-linked dimer, mol wt ~28-33 kDa. Prepn: E. A. Wang et al., WO 8800205; eidem, US 5013649 (1988, 1991 both to Genetics Institute); E. A. Wang et al., Proc. Natl. Acad. Sci. USA 87, 2220 (1990). Clinical trial of collagen sponge implant in tibial fractures: S. Govender et al., J. Bone Joint Surg. 84-A, 2123 (2002). Review of clinical trials in spinal fusion: S. N. Khan, J. M. Lane, Expert Opin. Biol. Ther. 4, 741-748 (2004).
Therap-Cat: Osteoinductive agent.
Keywords: Osteoinductive Agent.

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