Butalamine
Title: Butalamine
CAS Registry Number: 22131-35-7
CAS Name: N,N-Dibutyl-N¢-(3-phenyl-1,2,4-oxadiazol-5-yl)-1,2-ethanediamine
Additional Names: 5-[[2-(dibutylamino)ethyl]amino]-3-phenyl-1,2,4-oxadiazole; 3-phenyl-5-(dibutylaminoethylamino)-1,2,4-oxadiazole
Molecular Formula: C18H28N4O
Molecular Weight: 316.44
Percent Composition: C 68.32%, H 8.92%, N 17.71%, O 5.06%
Literature References: Prepn: FR M3334; Aron-Samuel, Sterne, US 3338899 (1965, 1967 to Aron-Samuel). Pharmacology and toxicity studies: J. Sterne et al., Therapie 24, 735 (1969); J. Sterne, ibid. 745; J. L. Fontaine, R. Fontaine, ibid. 25, 961 (1970).
 
Derivative Type: Hydrochloride
CAS Registry Number: 56974-46-0
Manufacturers' Codes: LA-1221
Trademarks: Adrevil (Zyma); Hemotrope (Andromaco); Surem (Novartis); Surheme (Merck KGaA)
Molecular Formula: C18H28N4O.HCl
Molecular Weight: 352.90
Percent Composition: C 61.26%, H 8.28%, N 15.88%, O 4.53%, Cl 10.05%
Properties: mp 145°. LD50 in mice (mg/kg): 43 i.v., 2500 s.c., 625 orally; LD50 in rats (mg/kg): >4000 s.c., 1600 orally (Sterne).
Melting point: mp 145°
Toxicity data: LD50 in mice (mg/kg): 43 i.v., 2500 s.c., 625 orally; LD50 in rats (mg/kg): >4000 s.c., 1600 orally (Sterne)
 
Therap-Cat: Vasodilator (peripheral).
Keywords: Vasodilator (Peripheral).

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