Candoxatril
Title: Candoxatril
CAS Registry Number: 123122-55-4
CAS Name: [4(S)-cis]-4-[[[1-[3-[(2,3-Dihydro-1H-inden-5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]cyclohexanecarboxylic acid
Additional Names: (aS)-1-[(cis-4-carboxycyclohexyl)carbamoyl]-a-[(2-methoxyethoxy)methyl]cyclopentanepropionic acid a-5-indanyl ester; (S)-cis-4-[1-[2-(5-indanyloxycarbonyl)-3-(2-methoxyethoxy)propyl]-1-cyclopentanecarboxamido]-1-cyclohexanecarboxylic acid
Manufacturers' Codes: UK-79300
Molecular Formula: C29H41NO7
Molecular Weight: 515.64
Percent Composition: C 67.55%, H 8.01%, N 2.72%, O 21.72%
Literature References: Neutral endopeptidase inhibitor. Prepn: I. T. Barnish et al., EP 274234; eidem, US 5030654 (1988, 1991 both to Pfizer). Enzyme inhibition and pharmacology: J. C. Danilewicz et al., Biochem. Biophys. Res. Commun. 164, 58 (1989). Clinical pharmacokinetics and effect on plasma ANP: J. G. Motwani et al., Clin. Pharmacol. Ther. 54, 661 (1993). Clinical evaluation in congestive heart failure: C. D. Kimmelstiel et al., Cardiology 87, 46 (1996).
Properties: White crystals, mp 107-109°. [a]D -5.8° (c = 1 in methanol).
Melting point: mp 107-109°
Optical Rotation: [a]D -5.8° (c = 1 in methanol)
 
Derivative Type: Diacid
CAS Registry Number: 123122-54-3
Additional Names: Candoxatrilat
Manufacturers' Codes: UK-73967
Molecular Formula: C20H33NO7
Molecular Weight: 399.48
Percent Composition: C 60.13%, H 8.33%, N 3.51%, O 28.04%
Properties: White crystals from ethyl acetate, mp 108.5-109.1°. [a]D +1.4° (c = 1 in methanol).
Melting point: mp 108.5-109.1°
Optical Rotation: [a]D +1.4° (c = 1 in methanol)
 
Therap-Cat: In treatment of congestive heart failure.
Keywords: Neutral Endopeptidase Inhibitor.

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