Caspase-8
Title: Caspase-8
CAS Registry Number: 179241-78-2
Additional Names: FADD-like ICE; FLICE; MACH; MORT1-associated CED-3 homolog; Mch5
Literature References: Initiator caspase required for Fas/CD95/APO-1-mediated apoptosis. Synthesized as a 55 kDa inactive zymogen, procaspase-8. Activated by association with the death-inducing signaling complex (DISC), leading to the release of active ~12 and ~20 kDa subunits into the cytosol. Isoln, characterization, and apoptotic function: M. P. Boldin et al., Cell 85, 803 (1996); M. Muzio et al., ibid. 817. DISC binding and activation: J. P. Medema et al., EMBO J. 16, 2794 (1997). Expression and characterization of isoforms: C. Scaffidi et al., J. Biol. Chem. 272, 26953 (1997). Activation of caspase-3, q.v.: H. R. Stennicke et al., ibid. 273, 27084 (1998). Cleavage of the proapoptotic Bcl2 protein, BID: H. Li et al., Cell 94, 491 (1998). Role in Fas-mediated apoptosis: P. Juo et al., Curr. Biol. 8, 1001 (1998). X-ray crystal structure of complexes with peptide inhibitors: H. Blanchard et al., Structure Fold. Des. 7, 1125 (1999); W. Watt et al., ibid. 1135. Role in lymphocyte activation: H. J. Chun et al., Nature 419, 395 (2002). Review: M. Kruidering, G. I. Evan, IUBMB Life 50, 85-90 (2000).

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