Ceftazidime
Title: Ceftazidime
CAS Registry Number: 72558-82-8
CAS Name: 1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium inner salt
Additional Names: 1-[[(6R,7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium hydroxide inner salt 72-(Z)-[O-(1-carboxy-1-methylethyl)oxime]
Manufacturers' Codes: GR-20263
Molecular Formula: C22H22N6O7S2
Molecular Weight: 546.58
Percent Composition: C 48.34%, H 4.06%, N 15.38%, O 20.49%, S 11.73%
Literature References: Third generation cephalosporin antibiotic. Prepn: C. H. O'Callaghan et al., DE 2921316; eidem, US 4258041 (1979, 1981 both to Glaxo). Prepn of crystalline pentahydrate: A. Brodie, L. A. Wetherill, DE 3037102; eidem, US 4329453 (1981, 1982 both to Glaxo). Chemical and antibacterial properties: eidem, Antimicrob. Agents Chemother. 17, 876 (1980). Activity vs Pseudomonas and Enterobacteriaceae: L. Verbist, J. Verhaegen, ibid. 807. In vitro comparison with other b-lactams: R. Wise et al., ibid. 884; L. Verbist, ibid. 19, 407 (1981). Symposium on clinical studies: J. Antimicrob. Chemother. 12, Suppl. A, 1-414 (1983). Review of antibacterial activity, pharmacokinetics and therapeutic use: D. M. Richards, R. N. Brogden, Drugs 29, 105-161 (1985). Comprehensive description: M. A. Abounassif et al., Anal. Profiles Drug Subs. 19, 95-121 (1990).
 
Derivative Type: Pentahydrate
CAS Registry Number: 78439-06-2
Trademarks: Fortam (GSK); Fortaz (GSK); Fortum (GSK); Fortumset (GSK); Glazidim (GSK); Kefadim (Lilly); Kefamin (Lilly); Kefazim (Lilly); Modacin (GSK); Panzid (Duncan); Spectrum (Sigma-Tau); Starcef (Firma); Tazicef (GSK); Tazidime (Lilly)
Molecular Formula: C22H22N6O7S2.5H2O
Molecular Weight: 636.65
Percent Composition: C 41.50%, H 5.07%, N 13.20%, O 30.16%, S 10.07%
Properties: Crystalline solid. uv max (pH 6): 257 nm (E1%1cm 348).
Absorption maximum: uv max (pH 6): 257 nm (E1%1cm 348)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.

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