Chloroprednisone
Title: Chloroprednisone
CAS Registry Number: 52080-57-6
CAS Name: (6a)-Chloro-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
Additional Names: 6a-chloro-1,4-pregnadiene-17a,21-diol-3,11,20-trione
Molecular Formula: C21H25ClO5
Molecular Weight: 392.87
Percent Composition: C 64.20%, H 6.41%, Cl 9.02%, O 20.36%
Literature References: Prepn: Batres et al., DE 1079042 (1960 to Syntex). Prepn of the 21-acetate by selenium dioxide dehydrogenation of 6a-chlorocortisone 21-acetate: Ringold et al., J. Am. Chem. Soc. 80, 6464 (1958); Ringold, Rosenkranz, US 2957895 (1960 to Syntex).
 
Derivative Type: 21-Acetate
CAS Registry Number: 14066-79-6
Trademarks: Topilan (Syntex)
Molecular Formula: C23H27ClO6
Molecular Weight: 434.91
Percent Composition: C 63.52%, H 6.26%, Cl 8.15%, O 22.07%
Properties: Crystals from acetone + hexane, mp 217-219°. uv max (ethanol): 237 nm (log e 4.19). [a]D +144° (chloroform).
Melting point: mp 217-219°
Optical Rotation: [a]D +144° (chloroform)
Absorption maximum: uv max (ethanol): 237 nm (log e 4.19)
 
Therap-Cat: Glucocorticoid (topical).
Keywords: Glucocorticoid.

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