Cortol
Title: Cortol
CAS Registry Number: 516-38-1
CAS Name: (3a,5b,11b,20S)-Pregnane-3,11,17,20,21-pentol
Molecular Formula: C21H36O5
Molecular Weight: 368.51
Percent Composition: C 68.44%, H 9.85%, O 21.71%
Literature References: Isolated from human urine after administration of hydrocortisone or ACTH: Fukushima et al., J. Biol. Chem. 212, 449 (1955).
 
Derivative Type: a-Cortol
Additional Names: 5b-Pregnane-3a,11b,17,20a,21-pentol
Properties: Crystals from ethyl acetate, mp 250.5-254°. [a]D26 +23.7° (ethanol).
Melting point: mp 250.5-254°
Optical Rotation: [a]D26 +23.7° (ethanol)
 
Derivative Type: a-Cortol 3,20,21-triacetate
Molecular Formula: C27H42O8
Molecular Weight: 494.62
Percent Composition: C 65.56%, H 8.56%, O 25.88%
Properties: Crystals from benzene + cyclohexane, mp 168-170°.
Melting point: mp 168-170°
 
Derivative Type: b-Cortol
Additional Names: 5b-Pregnane-3a,11b,17,20b,21-pentol
Properties: Crystals from methanol, mp 262-264.5°. [a]D25 +33.3° (ethanol).
Melting point: mp 262-264.5°
Optical Rotation: [a]D25 +33.3° (ethanol)

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