Coumachlor
Title: Coumachlor
CAS Registry Number: 81-82-3
CAS Name: 3-[1-(4-Chlorophenyl)-3-oxobutyl]-4-hydroxy-2H-1-benzopyran-2-one
Additional Names: 3-(a-acetonyl-p-chlorobenzyl)-4-hydroxycoumarin; 3-(a-p-chlorophenyl-b-acetylethyl)-4-hydroxycoumarin
Manufacturers' Codes: G-21133
Molecular Formula: C19H15ClO4
Molecular Weight: 342.77
Percent Composition: C 66.58%, H 4.41%, Cl 10.34%, O 18.67%
Literature References: Structural analog of warfarin. Prepn: F. Litvan, W. Stoll, US 2648682 (1953 to J. R. Geigy). Anticoagulant activity: M. Reiff, R. Weismann, Acta Trop. 8, 97 (1951), C.A. 50, 10976d (1956). Review of comparative toxicology: H. Wanntorp, Acta Pharmacol. Toxicol. 16, Suppl. 2, 123 pp (1959).
Properties: Crystals, mp 169-171°. Sol in alc, acetone, chloroform. Slightly sol in benzene, ether. Practically insol in water. MLD in dog, swine (mg/kg): <5, <5 orally (Wanntorp).
Melting point: mp 169-171°
Toxicity data: MLD in dog, swine (mg/kg): <5, <5 orally (Wanntorp)
CAUTION: Similar to warfarin, with delayed actions on prothrombin level and blood clotting, resulting in death by hemorrhage. See Clinical Toxicology of Commercial Products, R.E. Gosselin et al., Eds. (Williams & Wilkins, Baltimore, 5th ed., 1984) Section II, pp 348.
Use: Rodenticide.

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