Dapiprazole
Title: Dapiprazole
CAS Registry Number: 72822-12-9
CAS Name: 5,6,7,8-Tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-1,2,4-triazolo[4,3-a]pyridine
Additional Names: 5,6,7,8-tetrahydro-3-[2-(4-o-tolyl-1-piperazinyl)ethyl]-s-triazolo[4,3-a]pyridine
Molecular Formula: C19H27N5
Molecular Weight: 325.45
Percent Composition: C 70.12%, H 8.36%, N 21.52%
Literature References: a-Adrenergic blocker. Prepn: B. Silvestrini, L. Baiocchi, DE 2915318; eidem, US 4252721 (1979, 1981 both to Angelini Francesco). Series of articles on general pharmacology: Arzneim.-Forsch. 32, 674-681 (1982); and toxicity: B. Silvestrini et al., ibid. 668. Ocular pharmacokinetics in rabbits: P. Valeri et al., Pharmacol. Res. Commun. 18, 1093 (1986). Topical effects in human eye: A. Reibaldi et al., Acta Ther. 10, 381 (1984); C. Malpassi et al., ibid. 12, 55 (1986). Clinical trial in reversal of mydriasis: R. W. Allinson et al., Ann. Ophthalmol. 22, 131 (1990).
Properties: mp 158-160°.
Melting point: mp 158-160°
 
Derivative Type: Monohydrochloride
CAS Registry Number: 72822-13-0
Manufacturers' Codes: AF-2139
Trademarks: Glamidolo (Angelini); Reversil (Angelini); Rev-Eyes (Angelini)
Molecular Formula: C19H27N5.HCl
Molecular Weight: 361.91
Percent Composition: C 63.06%, H 7.80%, N 19.35%, Cl 9.80%
Properties: Crystals from absolute ethanol, mp 206-207°. LD50 in mice (mg/kg): 260 i.p. (Silvestrini).
Melting point: mp 206-207°
Toxicity data: LD50 in mice (mg/kg): 260 i.p. (Silvestrini)
 
Therap-Cat: Antiglaucoma; miotic.
Keywords: a-Adrenergic Blocker; Antiglaucoma.

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