Dichloralphenazone
Title: Dichloralphenazone
CAS Registry Number: 480-30-8
CAS Name: 1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one compd with 2,2,2-trichloro-1,1-ethanediol(1:2)
Additional Names: dichloralantipyrine
Trademarks: Bonadorm (Smith & Nephew); Dormwell (Smith & Nephew); Welldorm (Smith & Nephew)
Molecular Formula: C15H18Cl6N2O5
Molecular Weight: 519.03
Percent Composition: C 34.71%, H 3.50%, Cl 40.98%, N 5.40%, O 15.41%
Line Formula: [CCl3CH(OH)2]2.C11H12N2O
Literature References: Prepn: Pfeiffer, Seidel, Z. Physiol. Chem. 178, 97 (1928). GLC determn in pharmaceutical formulation: F. M. Plakogiannis, A. M. Saad, J. Pharm. Sci. 66, 604 (1977). Clinical trial of combination with isometheptene and acetaminophen, q.q.v., in treatment of migraine: S. Diamond, Headache 15, 282 (1976).
Properties: Small prismatic needles from water, mp 68°.
Melting point: mp 68°
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Chloral Derivatives.

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