Dimetofrine
Title: Dimetofrine
CAS Registry Number: 22950-29-4
CAS Name: 4-Hydroxy-3,5-dimethoxy-a-[(methylamino)methyl]benzenemethanol
Additional Names: 1-(3,5-dimethoxy-4-hydroxyphenyl)-2-(methylamino)ethanol; dimethophrine; dimetrophine
Molecular Formula: C11H17NO4
Molecular Weight: 227.26
Percent Composition: C 58.14%, H 7.54%, N 6.16%, O 28.16%
Literature References: Selective a1-adrenergic receptor agonist. Prepn: GB 1145637; M. Giani et al., US 3646144 (1969, 1972 both to Zambeletti). Pharmacology: Scrollini et al., Atti Accad. Med. Lomb. 25, 193, 203 (1970), C.A. 76, 54270a, 54425e (1972). Pharmacokinetics and metabolism: P. Boselli et al., Arzneim.-Forsch. 26, 2038 (1976); M. S. Benedetti et al., ibid. 27, 158 (1977). TLC determn: G. Musumarra et al., J. Chromatogr. 350, 151 (1985). Double blind clinical evaluations: V. Baldrighi et al., Curr. Med. Res. Opin. 9, 78 (1984); U. Marini et al., ibid. 265.
Properties: mp 178° (dec). pK 9.71.
Melting point: mp 178° (dec)
pKa: pK 9.71
 
Derivative Type: Hydrochloride
CAS Registry Number: 22775-12-8
Trademarks: Pressamina (Zambeletti)
Molecular Formula: C11H17NO4.HCl
Molecular Weight: 263.72
Percent Composition: C 50.10%, H 6.88%, N 5.31%, O 24.27%, Cl 13.44%
Properties: mp 171-173°.
Melting point: mp 171-173°
 
Therap-Cat: Antihypotensive.
Keywords: a-Adrenergic Agonist; Antihypotensive.

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