Dromostanolone
Title: Dromostanolone
CAS Registry Number: 58-19-5
CAS Name: (2a,5a,17b)-17-Hydroxy-2-methyl-androstan-3-one
Additional Names: 17b-hydroxy-2a-methyl-5a-androstan-3-one; 2a-methylandrostan-17b-ol-3-one; 2a-methyldihydrotestosterone; drostanolone
Molecular Formula: C20H32O2
Molecular Weight: 304.47
Percent Composition: C 78.90%, H 10.59%, O 10.51%
Literature References: Synthetic estrogen antagonist. Prepn: H. J. Ringold et al., J. Am. Chem. Soc. 81, 427 (1959); H. J. Ringold, G. Rosenkranz, US 3118915 (1964 to Syntex). GC-MS determn of urinary metabolites: D. DeBoer et al., J. Steroid Biochem. Mol. Biol. 42, 411 (1992).
Properties: Crystals from acetone/hexane, mp 149-153°. [a]D +32° (ethanol).
Melting point: mp 149-153°
Optical Rotation: [a]D +32° (ethanol)
 
Derivative Type: Propionate
CAS Registry Number: 521-12-0
Manufacturers' Codes: NSC-12198
Trademarks: Drolban (Lilly); Emdisterone; Masterid (Grñenthal); Masteril (Syntex); Masterone (Syntex); Permastril (Cassenne)
Molecular Formula: C23H36O3
Molecular Weight: 360.53
Percent Composition: C 76.62%, H 10.06%, O 13.31%
Properties: Crystals from hexane, mp 126-130°. [a]D +24°.
Melting point: mp 126-130°
Optical Rotation: [a]D +24°
 
NOTE: This is a controlled substance (anabolic steroid): 21 CFR, 1308.13, as defined in 1300.01.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic (Hormonal); Androgens.

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