Enflurane
Title: Enflurane
CAS Registry Number: 13838-16-9
CAS Name: 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
Additional Names: 2-chloro-1,1,2-trifluoroethyl difluoromethyl ether; methylflurether
Manufacturers' Codes: compd 347; NSC-115944
Trademarks: Alyrane (Baxter); Efrane (Abbott); Ethrane (Baxter)
Molecular Formula: C3H2ClF5O
Molecular Weight: 184.49
Percent Composition: C 19.53%, H 1.09%, Cl 19.22%, F 51.49%, O 8.67%
Line Formula: CHF2OCF2CHClF
Literature References: Prepn by fluorination of the corresp dichloromethyl ether: R. C. Terrell, GB 1138406; idem, US 3469011; US 3527813 (1969, 1969, 1970 all to Air Reduction). Synthesis and anesthetic properties: R. C. Terrell et al., J. Med. Chem. 14, 517 (1971); 15, 604 (1972). Enantiomeric resolution: J. Meinwald et al., Science 251, 560 (1991).
Properties: Stable, volatile, non-flammable liq. bp 56.5°. nD20 1.3025. d2525 1.5167. Does not degrade in the presence of alkali or light. Miscible with other organic liquids incl. fats and oils.
Boiling point: bp 56.5°
Index of refraction: nD20 1.3025
Density: d2525 1.5167
CAUTION: Potential symptoms of overexposure are eye irritation; CNS depression, analgesia, anesthesia, seizures, respiratory depression. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 128.
Therap-Cat: Anesthetic (inhalation).
Keywords: Anesthetic (Inhalation).

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