Ethanolamine
Title: Ethanolamine
CAS Registry Number: 141-43-5
CAS Name: 2-Aminoethanol
Additional Names: monoethanolamine; b-aminoethyl alcohol; 2-hydroxyethylamine; b-hydroxyethylamine; ethylolamine; colamine
Molecular Formula: C2H7NO
Molecular Weight: 61.08
Percent Composition: C 39.33%, H 11.55%, N 22.93%, O 26.19%
Line Formula: HOCH2CH2NH2
Literature References: Prepd on a large scale by ammonolysis of ethylene oxide: Knorr, Ber. 30, 909 (1897); FR 650574 (1928 to I. G. Farben); Reid, Lewis, US 1904013 (1933 to Carbide & Carbon); Schwoegler, Olin, US 2373199 (1945 to Sharples). Also from nitromethane and formaldehyde: Ullmanns Encyklopädie der technischen Chemie 3, 102 (3rd ed., 1953). Manuf: Faith, Keyes & Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 339-344. Toxicity: H. F. Smyth et al., J. Ind. Hyg. Toxicol. 23, 259 (1941).
Properties: Viscous, hygroscopic liq. Ammoniacal odor. Absorbs CO2. d425 1.0117; d440 0.9998; d460 0.9844. One gallon weighs 8.45 lbs in the U.S.A. Viscosity at 25°: 18.95 cP; at 60°: 5.03 cP. mp 10.3°. bp760 170.8°; bp12 70-72°. Strong base. pKa at 25°: 9.4. pH of 25% aq soln: 12.1; of 0.1N aq soln: 12.05. nD20 1.4539. Dipole moment 2.27. Flash pt 195°F. Misc with water, methanol, acetone. Soly at 25°: benzene 1.4%; ether 2.1%; carbon tetrachloride 0.2%; n-heptane <0.1%. LD50 orally in rats: 10.20 g/kg (Smyth).
Melting point: mp 10.3°
Boiling point: bp760 170.8°; bp12 70-72°
Flash point: Flash pt 195°F
pKa: pKa at 25°: 9.4
Index of refraction: nD20 1.4539
Density: d425 1.0117; d440 0.9998; d460 0.9844
Toxicity data: LD50 orally in rats: 10.20 g/kg (Smyth)
 
Derivative Type: Hydrochloride
Molecular Formula: C2H7NO.HCl
Molecular Weight: 97.54
Percent Composition: C 24.63%, H 8.27%, N 14.36%, O 16.40%, Cl 36.35%
Properties: Deliquesc crystals from alc, mp 75-77°.
Melting point: mp 75-77°
 
Derivative Type: Oleate
CAS Registry Number: 2272-11-9
Trademarks: Antivariz; Esclerosina; Ethamolin (Schwarz)
Molecular Formula: C2H7NO.C18H34O2
Molecular Weight: 343.54
Percent Composition: C 69.92%, H 12.03%, N 4.08%, O 13.97%
Literature References: Use as a sclerosing agent: S. E. Hedberg et al., Am. J. Surg. 143, 426 (1982).
 
CAUTION: Potential symptoms of overexposure to ethanolamine are irritation of eyes, skin, respiratory system; lethargy. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 128.
Use: To remove CO2 and H2S from natural gas and other gases; in the synthesis of surface active agents; in polishes, hair waving solns, in emulsifiers; as softening agent for hides; dispersing agent for agricultural chemicals. Is reacted with other substances to form an accelerator in the manuf of antibiotics. Pharmaceutic aid (surfactant).
Therap-Cat: Oleate as sclerosing agent.
Keywords: Sclerosing Agent.

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