Fenbufen
Title: Fenbufen
CAS Registry Number: 36330-85-5
CAS Name: g-Oxo-[1,1¢-biphenyl]-4-butanoic acid
Additional Names: 3-(4-biphenylylcarbonyl)propionic acid; b-p-phenylbenzoylpropionic acid; diphenyl-4-g-oxo-g-butyric acid; 4-(4-biphenylyl)-4-oxobutyric acid
Manufacturers' Codes: CL-82204
Trademarks: Bufemid (Lederle); Cinopal (Lederle); Cinopol (Lederle); Lederfen (Am. Cyanamid)
Molecular Formula: C16H14O3
Molecular Weight: 254.28
Percent Composition: C 75.57%, H 5.55%, O 18.88%
Literature References: Prepn: FR 798941 (1936 to I. G. Farbenind.), C.A. 30, 77294 (1936); D. H. Hey, R. Wilkinson, J. Chem. Soc. 1940, 1030; cf. M. Weizmann et al., Chem. Ind. (London) 1940, 402; W. Reppe et al., Ann. 596, 223 (1955); A. S. Tomcufcik et al., DE 2147111; eidem, US 3784701 (1972, 1974 to Am. Cyanamid). Series of articles on chemistry, pharmacology, reproductive toxicology and clinical experience: Arzneim.-Forsch. 30, 695-720, 725-746 (1980). Toxicity: H. F. Bolte et al., ibid. 721. Review of pharmacology and therapeutic use: R. N. Brogden et al., Drugs 21, 1-22 (1981).
Properties: Crystals from ethanol, mp 185-187°. LD50 in various strains of mice, rats (mg/kg): 795-1673, 200-720 orally; 506-811, 265-575 i.p. (Bolte).
Melting point: mp 185-187°
Toxicity data: LD50 in various strains of mice, rats (mg/kg): 795-1673, 200-720 orally; 506-811, 265-575 i.p. (Bolte)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylbutyric Acid Derivatives.

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