Glycerol Formal
Title: Glycerol Formal
Additional Names: Methylidinoglycerol
Trademarks: Glicerinformal (Calipe); Sericosol N
Molecular Formula: C4H8O3
Molecular Weight: 104.10
Percent Composition: C 46.15%, H 7.75%, O 46.11%
Literature References: Mixture of isomeric a,- and a,b-forms prepd from glycerin and formaldehyde: M. Schultz, B. Tollens, Ann. 289, 20 (1895). Prepn and separation of isomers: H. Hibbert, N. M. Carter, J. Am. Chem. Soc. 50, 3120 (1928); J. D. van Roon, Rec. Trav. Chim. 48, 173 (1929). Prepn and pharmacology: P. Gimeno, ES 475962 (1979 to Calipe), C.A. 93, 26445u (1980). Toxicological evaluation for use as pharmaceutical solvent: D. M. Sanderson, J. Pharm. Pharmacol. 11, 150, 446 (1959). Teratogenicity studies: V. Aliverti et al., Arch. Sci. Biol. 61, 89 (1977); E. Giavini, M. Prati, Acta Anat. 106, 203 (1980).
Properties: Liquid, bp760 191-195°, bp20 95-97°. d420 1.215; nD20 1.451. Sol in water, alc, chloroform. pH of 10% soln: 4-6.5. LD50 in rats (ml/kg): 8.6 orally, 3.5 i.v. (Gimeno).
Boiling point: bp760 191-195°; bp20 95-97°
Index of refraction: nD20 1.451
Density: d420 1.215
Toxicity data: LD50 in rats (ml/kg): 8.6 orally, 3.5 i.v. (Gimeno)
 
Derivative Type: a,-Form
Additional Names: 1,3-Dioxan-5-ol; a,-methylene glycerin; a,-formaldehyde glycerol; 5-m-dioxanol
Properties: bp 193.8°. d425 1.2200. nD25 1.4527.
Boiling point: bp 193.8°
Index of refraction: nD25 1.4527
Density: d425 1.2200
 
Derivative Type: a,b-Form
Additional Names: 1,3-Dioxolane-4-methanol; a,b-methylene glycerin; a,b-formaldehyde glycerol; 4-(hydroxymethyl)-1,3-dioxolane
Properties: bp 192.5°. d425 1.2008. nD25 1.4469.
Boiling point: bp 192.5°
Index of refraction: nD25 1.4469
Density: d425 1.2008
 
Use: Pharmaceutic aid (solvent).

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