Homochlorcyclizine
Title: Homochlorcyclizine
CAS Registry Number: 848-53-3
CAS Name: 1-[(4-Chlorophenyl)phenylmethyl]hexahydro-4-methyl-1H-1,4-diazepine
Additional Names: N-(p-chlorobenzhydryl)-N¢-methylhomopiperazine; 1-(4-chlorodiphenylmethyl)-4-methyl-2,3,4,5,6,7-hexahydro-1,4-diazepine; 1-(p-chloro-a-phenylbenzyl)-4-methylhomopiperazine
Manufacturers' Codes: SA-97
Molecular Formula: C19H23ClN2
Molecular Weight: 314.85
Percent Composition: C 72.48%, H 7.36%, Cl 11.26%, N 8.90%
Literature References: Prepn: Weston, Sommers, US 2655498 (1953 to Abbott); eidem, J. Am. Chem. Soc. 76, 5805 (1954). HPLC determn of enantiomers in urine: M. Nishikata et al., J. Chromatogr. 612, 239 (1993).
Properties: bp0.8 177°. nD25 1.5804.
Boiling point: bp0.8 177°
Index of refraction: nD25 1.5804
 
Derivative Type: Dihydrochloride
CAS Registry Number: 1982-36-1
Trademarks: Curosajin (Merck KGaA); Homoclomin (Eisai)
Molecular Formula: C19H23ClN2.2HCl
Molecular Weight: 387.77
Percent Composition: C 58.85%, H 6.50%, Cl 27.43%, N 7.22%
Properties: Crystals from ethanol, mp 227-228°.
Melting point: mp 227-228°
 
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Piperazines.

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