Homocystine
Title: Homocystine
CAS Registry Number: 462-10-2
CAS Name: 4,4¢-Dithiobis[2-aminobutanoic acid]
Additional Names: 4,4¢-dithiobis[2-aminobutyric acid]
Molecular Formula: C8H16N2O4S2
Molecular Weight: 268.35
Percent Composition: C 35.81%, H 6.01%, N 10.44%, O 23.85%, S 23.90%
Literature References: Synthesis by the "malonate" method: Patterson, du Vigneaud, J. Biol. Chem. 111, 393 (1935); Shiroishi et al., Rep. Food Res. Inst. (Tokyo) 5, 75 (1951); du Vigneaud, Brown, Biochem. Prep. 5, 93 (1957); from 3,6-bis(b-chloroethyl)-2,5-dioxopiperazine: Snyder, Cannon, J. Am. Chem. Soc. 66, 511 (1944).
 
Derivative Type: DL-Form
Properties: Platelets from water, dec 263-265°. pK1 1.59; pK2 2.54; pK3 8.52; pK4 9.44.
pKa: pK1 1.59; pK2 2.54; pK3 8.52; pK4 9.44
 
Derivative Type: L-Form
Properties: Crystals, dec 281-284°. [a]D21 -16° (H2O); [a]D26 +79° (1.0N HCl).
Optical Rotation: [a]D21 -16° (H2O); [a]D26 +79° (1.0N HCl)
 
Derivative Type: D-Form
Properties: Crystals, dec 281-284°. [a]D21 +16° (H2O); [a]D26 -79° (1.0N HCl).
Optical Rotation: [a]D21 +16° (H2O); [a]D26 -79° (1.0N HCl)

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