HQNO
Title: HQNO
CAS Registry Number: 341-88-8
CAS Name: 2-Heptyl-4-quinolinol 1-oxide
Additional Names: 2-heptyl-4-hydroxyquinoline N-oxide
Molecular Formula: C16H21NO2
Molecular Weight: 259.34
Percent Composition: C 74.10%, H 8.16%, N 5.40%, O 12.34%
Literature References: Inhibitor of electron transport through the cytochrome bc1 segment of the respiratory chain. Isoln of the naturally occurring antagonist to dihydrostreptomycin from Pseudomonas pyocyanea: Hays et al., J. Biol. Chem. 159, 725 (1948); J. Lightbown, J. Gen. Microbiol. 11, iv (1954). Properties: J. W. Cornforth, A. T. James, Biochem. J. 58, xlviii (1954). Synthesis: eidem, ibid. 63, 124 (1956); D. E. Ames et al., J. Chem. Soc. 1956, 3079. Inhibition of electron transport: J. W. Lightbown, F. L. Jackson, Biochem. J. 63, 130 (1956); M. Avron, ibid. 78, 735 (1961); N. J. Jacobs, M. J. Wolin, Biochim. Biophys. Acta 69, 29 (1963). Effect on proton permeability of the mitochondrial membrane: K. Krab, M. Wikström, Biochem. J. 186, 637 (1980). Sites of inhibition: G. Izzo et al., FEBS Lett. 93, 320 (1978); M. Droppa et al., Z. Naturforsch. 36C, 109 (1981).
Properties: Crystals from methylethyl ketone, mp 156-157°.
Melting point: mp 156-157°

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