Insulin Glargine
Title: Insulin Glargine
CAS Registry Number: 160337-95-1
CAS Name: 21A-Glycine-30Ba-L-arginine-30Bb-L-arginine-insulin (human)
Additional Names: [Gly(A21),Arg(B31),Arg(B32)]insulin (human)
Manufacturers' Codes: HOE-901
Trademarks: Lantus (Aventis)
Literature References: Long-acting analog of human insulin produced by recombinant DNA technology. Prepn: M. Dörschug, DE 3837825; idem, US 5656722 (1990, 1997 both to Hoechst). Characterization of receptor interaction: L. Berti et al., Horm. Metab. Res. 30, 123 (1998). Clinical pharmacodynamics: L. Heinemann et al., Diabetes Care 23, 644 (2000); pharmacokinetics: D. R. Owens et al., ibid. 813. Clinical trial in type 1 diabetics: R. E. Ratner et al., ibid. 639. Review of clinical experience: P. S. Gillies et al., Drugs 59, 253-260 (2000).
Properties: pI 6.7. Sol in acid pH. Insol at physiological pH.
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Hormones/Analogs.

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